Description

2H-1-Benzopyran-4-Amine,3,4-Dihydro-,(4R)-(9Ci) is a chiral, enantiomerically pure chroman derivative, a key structural motif in medicinal chemistry. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of complex bioactive molecules. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and metabolic conditions.
• Asymmetric Synthesis: Utilized in the construction of complex, stereochemically defined molecules due to its (4R) chiral center, enabling the development of enantiomerically pure active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery programs.
• Chemical Biology Probes: Used in the development of molecular probes to study biological pathways and enzyme functions.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing of high-value, low-volume specialty chemicals for the life sciences industry.

Basic Information

Product Name	2H-1-Benzopyran-4-Amine,3,4-Dihydro-,(4R)-(9Ci)
CAS No.	210488-55-4
Molecular Formula	C9H11NO
Molecular Weight	149.19 g/mol
Synonyms	(4R)-3,4-Dihydro-2H-1-benzopyran-4-amine; (R)-3,4-Dihydro-2H-chromen-4-amine; (R)-Chroman-4-amine; (R)-4-Aminochroman; (4R)-4-Amino-3,4-dihydro-2H-chromene; (R)-4-Amino-3,4-dihydro-2H-1-benzopyran; (R)-4-Amino-3,4-dihydro-2H-chromene; (R)-3,4-Dihydro-2H-1-benzopyran-4-ylamine
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Every lot is characterized using advanced analytical techniques including Chiral HPLC and NMR to confirm identity and purity. Certificates of Analysis (COA) detailing specific test results, including assay and enantiomeric excess (ee), are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.