Description

(-)-1,2-Bis[(2R,5R)-Dimethylphospholano]Benzene(Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a high-purity, chiral organometallic complex widely recognized as a highly efficient asymmetric hydrogenation catalyst. Its value lies in its exceptional enantioselectivity and catalytic activity, enabling the production of single-enantiomer intermediates critical for advanced pharmaceuticals and fine chemicals. This catalyst is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in their synthetic processes.

Application

• Asymmetric Hydrogenation Catalyst: Primary application for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Key for manufacturing active pharmaceutical ingredients (APIs) requiring high enantiomeric purity, such as β-amino acids, unnatural amino acids, and chiral lactones.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Synthesis: Enables the production of enantiomerically pure flavors, fragrances, and other high-value specialty chemicals.
• Academic and Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed in scaling up asymmetric transformations from laboratory to pilot plant and commercial production scales.

Basic Information

Product Name	(-)-1,2-Bis[(2R,5R)-Dimethylphospholano]Benzene(Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	210057-23-1
Molecular Formula	C₂₄H₄₀BF₄P₂Rh
Molecular Weight	580.23 g/mol
Synonyms	(-)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) Tetrafluoroborate; (R,R)-Me-DuPhos Rhodium(I) Tetrafluoroborate COD Complex; [Rh((R,R)-Me-DuPhos)(COD)]BF₄; Rh-(R,R)-Me-DuPhos Catalyst; DuPhos-Rh Catalyst; Asymmetric Hydrogenation Catalyst Rh-MeDuPhos; (R,R)-1,2-Bis(2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium(I) tetrafluoroborate
EINECS	Contact for details

Quality Control

Our (-)-1,2-Bis[(2R,5R)-Dimethylphospholano]Benzene(Cyclooctadiene)Rhodium(I) Tetrafluoroborate is manufactured under strict quality systems to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR spectroscopy and HPLC analysis to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing specific analytical results are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic activity.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Rhodium Content	17.0 - 18.0 %
Enantiomeric Purity	≥ 99.0% ee (by chiral HPLC or NMR of derivative)
Solubility	Soluble in dichloromethane, acetone; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.