Description

2-Chloro-6-Methoxy-4-[2-(Trimethylsilyl)Ethynyl]-3-Pyridinol is a sophisticated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a chloro-methoxy substitution pattern and a protected ethynyl group, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a monomer or functionalization agent in the creation of advanced polymers and organic electronic materials.
• Chemical Synthesis: A valuable reagent for Sonogashira and other cross-coupling reactions, enabling the construction of complex alkynyl-substituted heterocycles.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Ligand & Catalyst Development: Potential building block for creating novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Chloro-6-Methoxy-4-[2-(Trimethylsilyl)Ethynyl]-3-Pyridinol
CAS No.	208519-38-4
Molecular Formula	C11H14ClNO2Si
Molecular Weight	255.77 g/mol
Synonyms	3-Pyridinol, 2-chloro-6-methoxy-4-[2-(trimethylsilyl)ethynyl]-; 2-Chloro-6-methoxy-4-((trimethylsilyl)ethynyl)pyridin-3-ol; 4-((Trimethylsilyl)ethynyl)-2-chloro-6-methoxypyridin-3-ol; 2-Chloro-4-ethynyl-6-methoxy-3-pyridinol trimethylsilyl ether; TMS-protected pyridinol alkyne; CAS 208519-38-4
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Methoxy-4-[2-(Trimethylsilyl)Ethynyl]-3-Pyridinol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production use. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.