Description

4-(Difluoromethylidene)Piperidine Hydrochloride is a high-value, fluorinated piperidine derivative used as a key synthetic intermediate in advanced organic chemistry. Its unique difluoromethylidene moiety makes it a critical building block for introducing fluorine atoms into target molecules, which is essential for modulating the physicochemical and biological properties of novel compounds. This material is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the research and synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty chemicals and advanced materials, including liquid crystals and polymers with specific electronic properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the "fluorine effect" on potency, metabolic stability, and membrane permeability.
• Chemical Biology: Used as a probe or tag in the development of molecular tools and diagnostic agents.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the incorporation of a difluoromethylene group adjacent to a nitrogen heterocycle.

Basic Information

Product Name	4-(Difluoromethylidene)Piperidine Hydrochloride
CAS No.	208245-66-3
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	4-(Difluoromethylene)piperidine hydrochloride; 4-(Difluoromethylidene)piperidine HCl; 1-(Difluoromethylene)piperidin-1-ium chloride; Piperidine, 4-(difluoromethylene)-, hydrochloride; 4,4-Difluoro-1,2,3,6-tetrahydropyridine hydrochloride (tautomeric form); 208245-66-3; 4-Difluoromethylidenepiperidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethylidene)Piperidine Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.