Description

4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid is a high-value, multifunctional heterocyclic building block characterized by its thiophene core, phenyl substituent, and trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable electronic and physicochemical properties. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for organic electronic materials, such as semiconductors for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Ligand & Catalyst Development: The carboxylic acid functionality allows for derivatization into chelating ligands for metal-catalyzed cross-coupling reactions.
• Fluorine Chemistry: An important substrate for studying structure-activity relationships (SAR) in fluorinated compounds due to the presence of the CF3 group.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic projects.

Basic Information

Product Name	4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid
CAS No.	208108-76-3
Molecular Formula	C12H7F3O2S
Molecular Weight	272.24 g/mol
Synonyms	5-(Trifluoromethyl)-4-phenylthiophene-2-carboxylic acid; 4-Phenyl-5-(trifluoromethyl)-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 4-phenyl-5-(trifluoromethyl)-; 208108-76-3; 4-Phenyl-5-trifluoromethylthiophene-2-carboxylic acid; 5-Trifluoromethyl-4-phenylthiophene-2-carboxylic acid; 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-intermediate synthesis and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect from moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.