Description

tert-Butyl 5-Amino-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylate Hydrochloride is a high-purity, protected bicyclic amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its rigid, constrained scaffold is essential for constructing complex molecular architectures with precise stereochemistry, which is a fundamental requirement in modern pharmaceutical development. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Peptidomimetic Chemistry: Used to introduce a conformationally restricted, bicyclic amino acid motif into peptide backbones to enhance metabolic stability and receptor selectivity.
• Ligand Synthesis for Catalysis: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Serves as a building block for creating molecular probes to study enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale manufacturing of complex drug candidates.
• Academic & Institutional Research: A valuable reagent for methodology development and exploring new chemical space in synthetic organic chemistry laboratories.

Basic Information

Product Name	tert-Butyl 5-Amino-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylate Hydrochloride
CAS No.	207405-66-1
Molecular Formula	C11H21N2O2•HCl
Molecular Weight	264.76 g/mol
Synonyms	2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-amino-, 1,1-dimethylethyl ester, hydrochloride (1:1); (1R,4S)-tert-Butyl 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate hydrochloride; (1S,4R)-tert-Butyl 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate hydrochloride; 5-Amino-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester hydrochloride; tert-Butyl 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate HCl; Bicyclic Proline Derivative; 2-AABH-OtBu•HCl
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-Amino-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylate Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All material is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, chiral purity, and impurity profile. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with each shipment, supporting compliance with internal specifications suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.