Description

tert-Butyl 4-(1,8-Naphthyridin-2-yl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for complex small molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in research laboratories for structure-activity relationship (SAR) studies and lead optimization programs due to its naphthyridine-piperidine core.
• API Synthesis: A key raw material in the development and scale-up production of Active Pharmaceutical Ingredients (APIs) with complex heterocyclic architectures.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chemical transformations.

Basic Information

Product Name	tert-Butyl 4-(1,8-Naphthyridin-2-yl)piperidine-1-carboxylate
CAS No.	206989-62-0
Molecular Formula	C18H23N3O2
Molecular Weight	313.40 g/mol
Synonyms	1-Boc-4-(1,8-naphthyridin-2-yl)piperidine; 1-(tert-Butoxycarbonyl)-4-(1,8-naphthyridin-2-yl)piperidine; 4-(1,8-Naphthyridin-2-yl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(1,8-naphthyridin-2-yl)-1-piperidinecarboxylate; 2-(1-Boc-4-piperidyl)-1,8-naphthyridine; BOC-4-(1,8-Naphthyridin-2-yl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(1,8-Naphthyridin-2-yl)piperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.