Description

2-Bromo-6-Nitro-4-(Trifluoromethyl)Phenol, also known as 3-Bromo-2-Hydroxy-5-(Trifluoromethyl)Nitrobenzene, is a high-value halogenated nitroaromatic compound featuring a trifluoromethyl group, making it a versatile and potent synthetic intermediate. Its unique structure is critical for introducing specific bromo, nitro, and trifluoromethyl functionalities into target molecules, enabling the development of compounds with enhanced biological activity and physicochemical properties. This advanced building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring halogenated aromatic cores for receptor binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments where the nitro and bromo groups are crucial for color development and fastness.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Chemical Biology Probes: Used in medicinal chemistry to create molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-Bromo-6-Nitro-4-(Trifluoromethyl)Phenol / 3-Bromo-2-Hydroxy-5-(Trifluoromethyl)Nitrobenzene
CAS No.	206759-48-0
Molecular Formula	C7H3BrF3NO3
Molecular Weight	285.00 g/mol
Synonyms	3-Bromo-2-hydroxy-5-(trifluoromethyl)nitrobenzene; 2-Bromo-6-nitro-4-(trifluoromethyl)phenol; 2-Hydroxy-3-bromo-5-(trifluoromethyl)nitrobenzene; 4-(Trifluoromethyl)-2-bromo-6-nitrophenol; Phenol, 2-bromo-6-nitro-4-(trifluoromethyl)-; Benzene, 3-bromo-2-hydroxy-5-(trifluoromethyl)-1-nitro-; 206759-48-0; BTNP
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-6-Nitro-4-(Trifluoromethyl)Phenol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.