Description

Ibritumomab Tiuxetan is a monoclonal antibody conjugate used as a targeted radiopharmaceutical therapeutic agent. This compound is critical for the precise delivery of radiation to specific cancer cells, minimizing damage to surrounding healthy tissue. It is primarily required by pharmaceutical manufacturers and research institutions developing advanced treatments for non-Hodgkin's lymphoma.

Application

• Primary active pharmaceutical ingredient (API) in the production of Zevalin® (Yttrium-90 Ibritumomab Tiuxetan).
• Key component in targeted radioimmunotherapy (RIT) for the treatment of relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma.
• Used in clinical research for investigating novel radioimmunoconjugate therapies for other CD20-positive malignancies.
• Essential material for pharmacokinetic and biodistribution studies in oncology drug development.
• Reference standard for quality control and analytical method development in radiopharmaceutical manufacturing.

Basic Information

Product Name	Ibritumomab Tiuxetan
CAS No.	206181-63-7
Molecular Formula	C6484H10006N1736O2011S42
Molecular Weight	Approx. 148 kDa
Synonyms	Yttrium Y 90 Ibritumomab Tiuxetan; Ibritumomab Tiuxtan; Anti-CD20 Monoclonal Antibody Tiuxetan Conjugate; Zevalin; IDEC-Y2B8; 90Y-Ibritumomab Tiuxetan; Tiuxetan, Ibritumomab; Monoclonal Antibody CD20, Tiuxetan Conjugate
EINECS	Contact for details

Quality Control

Our Ibritumomab Tiuxetan is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch is tested to ensure identity, purity, potency, and safety, with specifications aligned with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing tests for protein concentration, immunoreactivity, radiochemical purity (when applicable), endotoxin levels, and sterility is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. For long-term stability, store under an inert atmosphere to prevent oxidation. Allow to equilibrate to room temperature before opening to minimize moisture condensation. The product is for single use in a controlled laboratory setting only.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (HPLC/MS)	Conforms to reference standard
Protein Concentration	≥ 1.0 mg/mL (or as per COA)
Purity (SEC-HPLC)	≥ 95% Monomer
Immunoreactivity	≥ 70%
Tiuxetan-to-Antibody Ratio (TAR)	1.5 - 2.5
Endotoxin	< 5.0 EU/mg
Sterility (when supplied as solution)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.