Description

(E)-3-(1-Methyl-1H-Indol-3-Yl)Acrylic Acid CAS NO 205884-12-4 is a high-purity, synthetic indole derivative featuring an acrylic acid moiety, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its role as a key precursor for the development of novel bioactive molecules, particularly in medicinal chemistry and drug discovery programs. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents or functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Agrochemical Synthesis: Serves as a precursor for developing novel plant growth regulators or pesticides with indole-based structures.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, dyes, and functional polymers.
• Bioconjugation & Probe Development: The acrylic acid group allows for coupling reactions, useful in creating fluorescent probes or bioconjugates for diagnostic applications.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(E)-3-(1-Methyl-1H-Indol-3-Yl)Acrylic Acid
CAS No.	205884-12-4
Molecular Formula	C₁₂H₁₁NO₂
Molecular Weight	201.22 g/mol
Synonyms	(E)-3-(1-Methylindol-3-yl)acrylic acid; trans-3-(1-Methyl-1H-indol-3-yl)acrylic acid; 3-(1-Methyl-1H-indol-3-yl)-2-propenoic acid; 1-Methyl-3-(2-carboxyvinyl)indole; (E)-1-Methyl-3-(2-carboxyvinyl)indole; (E)-3-(1-Methyl-1H-indol-3-yl)propenoic acid; 205884-12-4; (E)-3-(1-Methylindol-3-yl)prop-2-enoic acid
EINECS	Contact for details

Quality Control

Our (E)-3-(1-Methyl-1H-Indol-3-Yl)Acrylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.