Description

Boc-D-3,4-Difluorophe CAS NO 205445-51-8 is a protected, non-natural amino acid derivative featuring a D-configuration and a difluorinated phenylalanine side chain, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide and peptidomimetic structures with enhanced metabolic stability and bioavailability. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic agents, enzyme inhibitors, and bioactive probes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to incorporate fluorinated amino acids into peptide backbones to modulate conformation, stability, and receptor binding affinity.
• Protease Inhibitor Development: Building block for creating potent and selective inhibitors targeting specific proteolytic enzymes.
• Chemical Biology & Probe Synthesis: Enables the labeling and study of biological processes using fluorinated peptide probes.
• Material Science: Potential monomer for synthesizing specialized polymers with unique surface properties.
• Agrochemical Research: Intermediate in the development of novel bioactive compounds with improved properties.

Basic Information

Product Name	Boc-D-3,4-Difluorophe
CAS No.	205445-51-8
Molecular Formula	C₁₄H₁₇F₂NO₄
Molecular Weight	301.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-3,4-difluorophenylalanine; Boc-D-3,4-Difluorophenylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(3,4-difluorophenyl)propanoic acid; Boc-D-F₂-Phe-OH; Boc-D-(3,4-F₂)Phe; tert-Butyl (R)-(3-(3,4-difluorophenyl)-1-hydroxy-1-oxopropan-2-yl)carbamate; BOC-D-3,4-DIFLUOROPHE
EINECS	Contact for details

Quality Control

Our Boc-D-3,4-Difluorophe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and pharmaceutical development. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.