Description

[R-(R*,S*)]-1-(Fluoro-18F)-4-(2-Nitro-1H-Imidazol-1-Yl)-2,3-Butanediol is a sophisticated radiochemical compound designed for advanced diagnostic imaging. This product is a key intermediate in the synthesis of hypoxia-specific positron emission tomography (PET) tracers, enabling the non-invasive visualization of low-oxygen (hypoxic) tissues. It is essential for pharmaceutical R&D, clinical research, and diagnostic imaging centers focused on oncology, cardiology, and neurology.

Application

• PET Tracer Precursor: Primary use as a critical building block for synthesizing [18F]FMISO ([18F]Fluoromisonidazole) and related hypoxia imaging agents.
• Oncology Research: Enables the study of tumor hypoxia, a key factor in cancer progression, treatment resistance, and patient prognosis.
• Cardiovascular Imaging: Used in research to identify ischemic heart tissue and assess myocardial viability.
• Neurological Studies: Facilitates research into stroke and other neurological conditions characterized by oxygen deprivation.
• Radiopharmaceutical Development: Serves as a reference standard and key intermediate in the development and quality control of new diagnostic radiopharmaceuticals.
• Academic & Clinical Research: Supports fundamental and translational research in molecular imaging and radiochemistry.

Basic Information

Item	Detail
Product Name	[R-(R*,S*)]-1-(Fluoro-18F)-4-(2-Nitro-1H-Imidazol-1-Yl)-2,3-Butanediol
CAS No.	204977-05-9
Molecular Formula	C7H9FN3O4
Molecular Weight	218.16 g/mol
Synonyms	1-(2-Nitro-1H-imidazol-1-yl)-3-[(1R,2S)-1-fluoro-18F-2,3-dihydroxypropyl]-2-propanol; FMISO Precursor; [18F]Fluoromisonidazole Precursor; (2R,3S)-1-(2-Nitroimidazol-1-yl)-3-(18F)fluoropropane-2,3-diol; Hypoxia Tracer Intermediate; Nitroimidazole Fluorine-18 Derivative; 1H-Imidazole, 1-[3-[(1R,2S)-1-fluoro-18F-2,3-dihydroxypropyl]-2-hydroxypropyl]-2-nitro-
EINECS	Contact for details

Quality Control

This high-purity radiochemical intermediate is produced under strict quality control protocols. Each batch is analyzed to ensure identity, purity, and radiochemical purity meet exacting standards for pharmaceutical research. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided. Our processes align with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chemical Purity	≥ 98%
Specific Activity	Contact for details
Radiochemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.