Description

2-Cyano-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and cyano-substituted structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in the development and optimization of commercial-scale API manufacturing routes.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structural features make it a potential component for constructing linkers or ligands in targeted protein degradation therapeutics.
• Chemical Biology Probe Synthesis: Utilized to create specialized molecules for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2-Cyano-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid tert-Butyl Ester
CAS No.	203662-66-2
Molecular Formula	C14H22N2O2
Molecular Weight	250.34 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-2-cyano-7-azaspiro[3.5]nonane; tert-Butyl 2-cyano-7-azaspiro[3.5]nonane-7-carboxylate; 2-Cyano-7-azaspiro[3.5]nonane-7-carboxylic acid 1,1-dimethylethyl ester; 7-Boc-2-cyano-7-azaspiro[3.5]nonane; 203662-66-2; Azaspiro[3.5]nonane-7-carboxylic acid, 2-cyano-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Cyano-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.