Description

1-Oxa-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and oxazolidinone-like structure. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and anti-infective applications. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those with spirocyclic or constrained heterocyclic architectures.
• API Synthesis: Serves as a key chiral building block for constructing complex Active Pharmaceutical Ingredients (APIs) in segments like neurology and anti-infectives.
• Medicinal Chemistry Research: Used in discovery labs for structure-activity relationship (SAR) studies and lead optimization due to its functionalized, three-dimensional scaffold.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical suppliers offering bespoke synthesis services to the pharma industry.
• Bioconjugation & Prodrug Development: The hydroxymethyl and ester functionalities make it suitable for designing prodrugs or conjugating with other molecular entities.

Basic Information

Product Name	1-Oxa-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester
CAS No.	203662-53-7
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	tert-Butyl 2-(hydroxymethyl)-1-oxa-7-azaspiro[3.5]nonane-7-carboxylate; 7-(tert-Butoxycarbonyl)-1-oxa-7-azaspiro[3.5]nonane-2-methanol; 2-(Hydroxymethyl)-1-oxa-7-azaspiro[3.5]nonane-7-carboxylic Acid tert-Butyl Ester; Boc-Protected 1-Oxa-7-Azaspiro[3.5]Nonane-2-Methanol; 1-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester; Spirocyclic Oxazolidinone Ester Intermediate
EINECS	Contact for details

Quality Control

Our production of 1-Oxa-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation (NMR, IR, MS). Certificates of Analysis (COA) documenting all release specifications are available for every batch. Our quality commitment aligns with cGMP principles where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be kept separate from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.