Description

2-Quinolinecarboxamide,n-[1-[[[4-Hydroxy-1-(Phenylmethyl)-3-Pyrrolidinyl]Amino]Carbonyl]-3-Methylbutyl]-n-Methyl-,[3(S)]-[Partial]-(9Ci) CAS NO 203502-18-5 is a sophisticated chiral organic compound featuring a quinolinecarboxamide core linked to a substituted pyrrolidine moiety. This complex molecular architecture makes it a valuable high-purity intermediate for advanced pharmaceutical research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of potential drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Biochemical Research: Used as a reference standard or a precursor in the study of enzyme-substrate interactions and structure-activity relationships (SAR).
• Organic Synthesis: Serves as a complex scaffold for medicinal chemists to develop novel compound libraries for high-throughput screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for advanced studies in synthetic organic chemistry and pharmacology.

Basic Information

Item	Detail
Product Name	2-Quinolinecarboxamide,n-[1-[[[4-Hydroxy-1-(Phenylmethyl)-3-Pyrrolidinyl]Amino]Carbonyl]-3-Methylbutyl]-n-Methyl-,[3(S)]-[Partial]-(9Ci)
CAS No.	203502-18-5
Molecular Formula	C28H36N4O3
Molecular Weight	476.62 g/mol
Synonyms	N-Methyl-N-[(3S)-1-({[(3S,4R)-4-hydroxy-1-benzylpyrrolidin-3-yl]amino}carbonyl)-3-methylbutyl]quinoline-2-carboxamide; (3S)-N-[1-[[[(3S,4R)-4-Hydroxy-1-benzyl-3-pyrrolidinyl]amino]carbonyl]-3-methylbutyl]-N-methyl-2-quinolinecarboxamide; 2-Quinolinecarboxamide, N-[1-[[[(3S,4R)-4-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]amino]carbonyl]-3-methylbutyl]-N-methyl-, (3S)-; A potential intermediate for Omapatrilat analogs.
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We adhere to ICH guidelines for stability and impurity profiling to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.