Description

4-Chloro-2-Fluorocinnamic Acid is a halogenated cinnamic acid derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents on the aromatic ring, makes it a valuable intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogen atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for synthesizing advanced organic electronic materials due to its conjugated system and halogen functionalities.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a precursor for other functionalized cinnamic acids and stilbenes.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries.

Basic Information

Product Name	4-Chloro-2-Fluorocinnamic Acid
CAS No.	202982-65-8
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	(E)-3-(4-Chloro-2-fluorophenyl)acrylic acid; 4-Chloro-2-fluorocinnamic acid; trans-4-Chloro-2-fluorocinnamic acid; 2-Fluoro-4-chlorocinnamic acid; (2E)-3-(4-Chloro-2-fluorophenyl)prop-2-enoic acid; 4-Chloro-2-fluoro-trans-cinnamic acid; 3-(4-Chloro-2-fluorophenyl)-2-propenoic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment ensures the material meets the high standards required for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.