Description

2-Bromo-5-Fluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in its unique halogenated structure, which enables precise molecular modifications essential for developing novel compounds. This intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small molecule drugs, particularly in kinase inhibitor and anti-inflammatory agent research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the bromo-fluoro substitution pattern enhances biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Peptidomimetic & Bio-conjugation Chemistry: The carboxylic acid group allows for amide bond formation, useful in creating peptide analogs and linker molecules.
• Academic & Contract Research: Employed in medicinal chemistry labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Bromo-5-Fluorocinnamic Acid
CAS No.	202865-70-1
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	(E)-3-(2-Bromo-5-fluorophenyl)acrylic acid; 2-Bromo-5-fluorocinnamic acid; trans-2-Bromo-5-fluorocinnamic acid; 3-(2-Bromo-5-fluorophenyl)-2-propenoic acid; (2E)-3-(2-Bromo-5-fluorophenyl)prop-2-enoic acid; α-Bromo-5-fluorocinnamic Acid; 2-Br-5-F-CA
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with lot-specific data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.