Description

Cyclohexanone, 5-Acetyl-3-Hydroxy-2-Methyl-, [2R-(2Alpha,3Alpha,5Beta)]- (9Ci) CAS NO 202859-82-3 is a high-purity, stereochemically defined derivative of cyclohexanone, serving as a critical chiral building block in advanced organic synthesis. Its precise stereochemistry and functional group array make it an invaluable intermediate for constructing complex molecular architectures with high enantiomeric purity. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, where it is used to synthesize active pharmaceutical ingredients (APIs), chiral ligands, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel, stereospecific active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high enantiopurity.
• Agrochemical Synthesis: Used in the research and production of advanced, optically active pesticides and herbicides, where the specific stereochemistry can influence biological activity.
• Fine Chemical & Catalyst Development: Serves as a precursor for chiral ligands, auxiliaries, and organocatalysts used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable reference standard and starting material in methodological development for new synthetic routes involving complex cyclohexanone frameworks.
• Specialty Polymer Monomer: Potential use in the synthesis of specialty polymers with tailored optical or mechanical properties derived from its chiral center.

Basic Information

Product Name	Cyclohexanone, 5-Acetyl-3-Hydroxy-2-Methyl-, [2R-(2Alpha,3Alpha,5Beta)]- (9Ci)
CAS No.	202859-82-3
Molecular Formula	C10H16O3
Molecular Weight	184.23 g/mol
Synonyms	(2R,3R,5S)-5-Acetyl-3-hydroxy-2-methylcyclohexan-1-one; (2R,3R,5S)-5-Acetyl-3-hydroxy-2-methylcyclohexanone; 5-Acetyl-3-hydroxy-2-methylcyclohexanone (stereoisomer); [2R-(2α,3α,5β)]-5-Acetyl-3-hydroxy-2-methylcyclohexanone; Chiral Cyclohexanone Derivative; (2R,3R,5S)-Form; Optically Active Cyclohexanone Intermediate
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided with every shipment. We support compliance with cGMP and ISO 9001 standards for relevant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Optical Rotation	Specific range provided on COA
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.