Description

1'H-Spiro[Piperidine-4,2'-Quinazolin]-4'(3'H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazolinone structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of proprietary drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Employed in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: A key starting material for developing novel compounds intended to interact with central nervous system receptors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1'H-Spiro[Piperidine-4,2'-Quinazolin]-4'(3'H)-One
CAS No.	202826-52-6
Molecular Formula	C12H13N3O
Molecular Weight	215.25 g/mol
Synonyms	Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one; 1'H-Spiro(piperidine-4,2'-quinazolin)-4'(3'H)-one; 4'(3'H)-Spiro[piperidine-4,2'-quinazolin]-1'H-one; Quinazolin-4(3H)-one, 1'H-spiro[piperidine-4,2'-; 202826-52-6; Spiroquinazolinone derivative; AQ-RA 741; AZD-1283 intermediate (related compound)
EINECS	Contact for details

Quality Control

Our 1'H-Spiro[Piperidine-4,2'-Quinazolin]-4'(3'H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.