Description

4-Chlorocatechol (13C6, 99%) is a stable isotope-labeled analog of 4-chlorocatechol, a key intermediate in the microbial degradation pathways of chlorinated aromatic compounds. This high-purity, carbon-13 labeled standard is essential for precise quantitative analysis and metabolic pathway tracing in environmental and biochemical research. It is primarily utilized by analytical chemists and researchers in the fields of environmental science, biodegradation studies, and pharmaceutical development who require reliable internal standards for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS and GC-MS analysis for environmental pollutant monitoring.
• Metabolic Pathway Tracing: Used in biodegradation and metabolic studies to track the fate of chlorinated aromatics using 13C-NMR.
• Environmental Analysis: Enables accurate quantification of 4-chlorocatechol and related degradation products in soil and water samples.
• Biochemical Research: Facilitates the study of enzyme mechanisms, such as those of dioxygenases, in the breakdown of chlorinated pollutants.
• Pharmaceutical Impurity Profiling: Acts as a reference standard in the analysis of potential genotoxic impurities (PGIs) in active pharmaceutical ingredients (APIs).
• Method Development and Validation: Essential for developing and validating robust analytical methods in compliance with ICH guidelines.

Basic Information

Product Name	4-Chlorocatechol (13C6, 99%)
CAS No.	201740-93-4
Molecular Formula	C6H4Cl2O2 (13C6)
Molecular Weight	166.00 (unlabeled); ~172.00 (13C6 labeled)
Synonyms	4-Chlorobenzene-1,2-diol (13C6); 4-Chloro-1,2-benzenediol (13C6); 4-Chloropyrocatechol (13C6); 1,2-Dihydroxy-4-chlorobenzene (13C6); 4-Chlorocatechol-13C6; 4-CC (13C6); [13C6]-4-Chlorocatechol; Uniformly Labeled 13C6 4-Chlorocatechol
EINECS	Contact for details

Quality Control

Every batch of 4-Chlorocatechol (13C6, 99%) is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing to ensure isotopic purity (≥99% 13C6), chemical purity (≥99%), and conformity to specification. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from NMR, MS, and HPLC analyses. Our quality commitment supports research requiring traceable and reliable isotopic standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Purity (13C6)	≥ 99%
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.