Description

β-[2-([2-(8-Azaspiro[4.5]Dec-8-Ylcarbonyl)-4,6-Dimethylphenyl]Amino)-2-Oxoethyl]-(R)-1-Naphthalenepropanoic Acid CAS NO 201605-51-8 is a sophisticated chiral organic compound featuring a complex molecular architecture that combines a naphthalene core with an azaspiro[4.5]decane moiety. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a potential key intermediate or active pharmaceutical ingredient (API) for novel therapeutics. It is primarily targeted at pharmaceutical companies, contract research organizations (CROs), and academic research institutions engaged in the synthesis of new chemical entities for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders or other specialized therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Used in research for the development and scale-up of new APIs, where its specific stereochemistry (R-configuration) is essential for biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency, selectivity, and pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of robust, scalable synthetic routes for GMP (Good Manufacturing Practice) production.
• Reference Standard: Supplied as a high-purity compound for use as an analytical reference standard in quality control (QC) and regulatory submissions.
• Biochemical Research: Potential use as a tool compound in biochemical assays to study specific enzyme or receptor interactions.

Basic Information

Item	Details
Product Name	β-[2-([2-(8-Azaspiro[4.5]Dec-8-Ylcarbonyl)-4,6-Dimethylphenyl]Amino)-2-Oxoethyl]-(R)-1-Naphthalenepropanoic Acid
CAS No.	201605-51-8
Molecular Formula	C34H38N2O4
Molecular Weight	538.68 g/mol
Synonyms	(R)-β-[2-([2-(8-Azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylphenyl]amino)-2-oxoethyl]-1-naphthalenepropanoic acid; (R)-2-(2-(2-(8-Azaspiro[4.5]decane-8-carbonyl)-4,6-dimethylphenylamino)-2-oxoethyl)-3-(naphthalen-1-yl)propanoic acid; UNII-9K5P8A5F8B; 9K5P8A5F8B; 1-Naphthalenepropanoic acid, β-[2-[[2-(8-azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylphenyl]amino]-2-oxoethyl]-, (R)-; (R)-3-(1-Naphthyl)-2-[2-[[2-(8-azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylphenyl]amino]-2-oxoethyl]propanoic acid
EINECS	Contact for details

Quality Control

Our β-[2-([2-(8-Azaspiro[4.5]Dec-8-Ylcarbonyl)-4,6-Dimethylphenyl]Amino)-2-Oxoethyl]-(R)-1-Naphthalenepropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing all critical quality attributes, including chiral purity and related substances. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.