Description

3,4-Dehydro-L-Proline Hydrochloride is a high-purity, non-proteinogenic amino acid derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a constrained proline analog, which is essential for modulating peptide conformation and stability in pharmaceutical research. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries for applications in drug discovery and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and peptidomimetics.
• Peptide Chemistry Research: Used as a constrained proline analog to study peptide secondary structure, stability, and receptor binding affinity.
• Drug Discovery & Development: Employed in medicinal chemistry for creating compound libraries and optimizing lead candidates with improved pharmacokinetic properties.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and as a tool compound for probing biological pathways.
• Agrochemical Synthesis: Utilized in the research and development of new pesticides and herbicides that require specific chiral centers.
• Academic & Institutional Research: A valuable reagent for universities and research institutes conducting studies in organic chemistry and chemical biology.

Basic Information

Product Name	3,4-Dehydro-L-Proline Hydrochloride
CAS No.	201469-31-0
Molecular Formula	C5H8ClNO2
Molecular Weight	149.57 g/mol
Synonyms	(2S)-3,4-Didehydropyrrolidine-2-carboxylic acid hydrochloride; L-3,4-Dehydroproline hydrochloride; (S)-3,4-Dehydroproline hydrochloride; δ3,4-L-Proline hydrochloride; 3,4-Didehydro-L-proline HCl; (S)-3,4-Didehydropyrrolidine-2-carboxylic acid hydrochloride; 3,4-Dehydro-L-proline HCl salt
EINECS	Contact for details

Quality Control

Our 3,4-Dehydro-L-Proline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.