Description

Z-Thr(Bzl)-Oh . Dcha is a protected amino acid derivative, specifically the Z-protected form of O-benzyl threonine as a dicyclohexylamine (DCHA) salt. This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering enhanced solubility and handling properties for the controlled introduction of threonine residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and therapeutic agents. The DCHA salt form provides improved crystallinity and stability, facilitating high-purity synthesis workflows.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the sequential assembly of peptide chains.
• Pharmaceutical Intermediate: In the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation & Labeling: For the site-specific modification of peptides and proteins where the threonine side chain is targeted.
• Combinatorial Chemistry: Used in libraries for drug discovery to explore structure-activity relationships (SAR).
• Academic & Industrial Research: A fundamental reagent for studying peptide structure, function, and stability.

Basic Information

Product Name	Z-Thr(Bzl)-Oh . Dcha
CAS No.	201275-72-1
Molecular Formula	C28H38N2O5
Molecular Weight	482.61 g/mol
Synonyms	Nα-Carbobenzyloxy-O-benzyl-L-threonine Dicyclohexylamine Salt; Z-O-Benzyl-L-threonine DCHA Salt; N-Cbz-O-Benzyl-L-threonine Dicyclohexylammonium Salt; (2S,3R)-2-[[(Benzyloxy)carbonyl]amino]-3-(benzyloxy)butanoic acid - Dicyclohexylamine (1:1); Z-Thr(Bzl)-OH·DCHA; Fmoc-Thr(Bzl)-OH precursor salt; Boc-Thr(Bzl)-OH analog salt; Protected L-Threonine DCHA Salt
EINECS	Contact for details

Quality Control

Our Z-Thr(Bzl)-Oh . Dcha is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.