Description

2-tert-Butyl-1,1,3,3-Tetramethylguanidine is a highly sterically hindered, strong organic base. This compound matters for its exceptional nucleophilicity and low basicity, making it a superior catalyst and reagent in demanding synthetic transformations where conventional bases fail. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries for applications such as asymmetric synthesis and polyurethane catalysis.

Application

• Pharmaceutical Synthesis: As a non-nucleophilic base for deprotonation and as a catalyst in the synthesis of active pharmaceutical ingredients (APIs), particularly in asymmetric reactions.
• Agrochemical Manufacturing: Utilized as a key reagent in the production of advanced pesticides and herbicides, where its steric bulk promotes selective reactions.
• Polymer & Polyurethane Catalyst: Acts as an efficient catalyst for the production of polyurethanes and other polymers, offering advantages in reaction rate and product properties.
• Organic Synthesis & Research: A valuable tool in academic and industrial R&D for C-C and C-N bond-forming reactions, including Henry reactions and cyclizations.
• Fine Chemical Production: Employed in the manufacture of complex dyes, flavors, and fragrances that require selective base catalysis under mild conditions.

Basic Information

Product Name	2-tert-Butyl-1,1,3,3-Tetramethylguanidine
CAS No.	29166-72-1
Molecular Formula	C9H21N3
Molecular Weight	171.28 g/mol
Synonyms	2-tert-Butyl-1,1,3,3-tetramethylguanidine; 1,1,3,3-Tetramethyl-2-tert-butylguanidine; TBTMG; 2-(tert-Butyl)-1,1,3,3-tetramethylguanidine; N,N,N',N'-Tetramethyl-N''-tert-butylguanidine; tert-Butyltetramethylguanidine; Guanidine, N,N,N',N'-tetramethyl-N''-(1,1-dimethylethyl)-; Strong organic base 2-tert-butyl-1,1,3,3-tetramethylguanidine
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl-1,1,3,3-Tetramethylguanidine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including assay and impurity profiling by GC/HPLC, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.