Description

11,12-Dihydro-11,12-Dihydroxybenzo(A)Pyrene is a key dihydrodiol metabolite of the polycyclic aromatic hydrocarbon Benzo(a)pyrene. This compound matters significantly as a crucial reference standard and intermediate in toxicological and environmental research, particularly for studying metabolic activation pathways and DNA adduct formation. Researchers and analytical laboratories in the pharmaceutical, environmental monitoring, and chemical safety sectors require this high-purity material for method development, calibration, and mechanistic studies.

Application

• Metabolite Reference Standard: Used as an analytical standard in HPLC, LC-MS, and GC-MS for the quantification of Benzo(a)pyrene metabolites in biological and environmental samples.
• Toxicology Research: Essential for in vitro and in vivo studies investigating the metabolic activation, carcinogenicity, and genotoxicity of polycyclic aromatic hydrocarbons (PAHs).
• Biomarker Studies: Employed in the development and validation of assays for detecting specific DNA or protein adducts, serving as biomarkers of PAH exposure.
• Enzymology Studies: Acts as a substrate or product in studies characterizing the activity of cytochrome P450 enzymes (e.g., CYP1A1) and epoxide hydrolases.
• Environmental Analysis: Supports method development for monitoring PAH transformation products and understanding their environmental fate.
• Chemical Synthesis Intermediate: Utilized as a building block in the organic synthesis of more complex derivatives for further biological testing.

Basic Information

Product Name	11,12-Dihydro-11,12-Dihydroxybenzo(A)Pyrene
CAS No.	28622-86-8
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.32 g/mol
Synonyms	11,12-Dihydro-11,12-dihydroxybenzo[a]pyrene; Benzo[a]pyrene 11,12-dihydrodiol; BP-11,12-diol; (+/-)-11,12-Dihydroxy-11,12-dihydrobenzo[a]pyrene; 11,12-Dihydroxy-11,12-dihydrobenzo(a)pyrene; B(a)P-11,12-dihydrodiol; Benzo(a)pyrene-11,12-diol
EINECS	Contact for details

Quality Control

Our 11,12-Dihydro-11,12-Dihydroxybenzo(A)Pyrene is manufactured and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for analytical reference materials to support your compliance and data integrity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.