Description

trans-2-Hydroxymethyl-1-Cyclohexylamine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a rigid cyclohexyl backbone with both amino and hydroxymethyl functional groups, enabling precise stereochemical control in complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel active pharmaceutical ingredients (APIs) and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where stereochemistry impacts biological activity.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• Peptidomimetics Research: Employed to introduce constrained cyclohexyl amino acid analogs into peptide chains to modify stability and bioavailability.
• Fine Chemical Production: A versatile intermediate for creating specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Item	Detail
Product Name	trans-2-Hydroxymethyl-1-Cyclohexylamine Hydrochloride
CAS No.	28250-45-5
Molecular Formula	C7H16ClNO
Molecular Weight	165.66 g/mol
Synonyms	(1R,2S)-2-(Aminomethyl)cyclohexanol Hydrochloride; (1R,2S)-2-(Hydroxymethyl)cyclohexylamine Hydrochloride; trans-2-(Aminomethyl)cyclohexanol HCl; (1R,2S)-2-Aminomethyl-1-cyclohexanol Hydrochloride; rel-(1R,2S)-2-(Aminomethyl)cyclohexanol Hydrochloride; trans-2-Aminomethylcyclohexanol Hydrochloride; (1R,2S)-1-Amino-2-hydroxymethylcyclohexane Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of trans-2-Hydroxymethyl-1-Cyclohexylamine Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.