Description

3-Azabicyclo[3.1.0]hexane-2-carboxylic acid is a high-value, conformationally constrained bicyclic proline derivative. This compound serves as a critical chiral building block and scaffold in advanced pharmaceutical synthesis, enabling the development of novel drug candidates with enhanced potency and selectivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of protease inhibitors, CNS-active agents, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitor research.
• Medicinal Chemistry Scaffold: Used as a rigid, bicyclic proline analog to explore structure-activity relationships (SAR) and improve metabolic stability in drug discovery programs.
• Peptidomimetics: Incorporated into peptide analogs to constrain backbone conformation and enhance binding affinity to biological targets.
• Chemical Biology Probes: Serves as a building block for creating tool compounds and probes to study enzyme function and biological pathways.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthetic routes.
• Academic & Industrial R&D: Fundamental research material in organic chemistry and pharmacology for method development and novel compound libraries.

Basic Information

Product Name	3-Azabicyclo[3.1.0]hexane-2-carboxylic Acid
CAS No.	27762-08-9
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	3-Azabicyclo[3.1.0]hexane-2-carboxylic acid; (1R,5S)-3-Azabicyclo[3.1.0]hexane-2-carboxylic acid; Bicycloproline; 2-Carboxy-3-azabicyclo[3.1.0]hexane; 3-Aza-bicyclo[3.1.0]hexane-2-carboxylic acid; 2,3-Methanoproline; 3-Azabicyclo[3.1.0]hexane-2-carboxylic acid hydrochloride (salt forms); 27762-08-9
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]hexane-2-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.