Description

(13As)-5,8,13,13Aα-Tetrahydro-2,11-Dimethoxy-6H-Dibenzo[A,G]Quinolizine-1,10-Diol is a complex, high-purity alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical advanced intermediate for developing novel therapeutic agents and complex molecular architectures. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel isoquinoline and protoberberine alkaloid derivatives with potential pharmacological activity.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies targeting central nervous system (CNS) disorders, antimicrobial agents, or anticancer compounds.
• Process Chemistry Development: Serves as a model compound for developing and optimizing scalable synthetic routes for complex heterocyclic systems.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and compound identification.
• Biochemical Research: Investigated for its potential interactions with biological targets such as enzymes or receptors in biochemical assays.
• Academic Synthesis: Used in advanced organic chemistry courses and research projects to demonstrate complex multi-step synthesis and purification techniques.

Basic Information

Item	Details
Product Name	(13As)-5,8,13,13Aα-Tetrahydro-2,11-Dimethoxy-6H-Dibenzo[A,G]Quinolizine-1,10-Diol
CAS No.	27498-04-0
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	2,11-Dimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine-1,10-diol; NSC 5109; Berbine derivative; 1,10-Dihydroxy-2,11-dimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine; (13aS)-1,10-Dihydroxy-2,11-dimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine; Tetrahydroberberine derivative
EINECS	Contact for details

Quality Control

Our (13As)-5,8,13,13Aα-Tetrahydro-2,11-Dimethoxy-6H-Dibenzo[A,G]Quinolizine-1,10-Diol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR, MS), and residual solvent analysis to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.