Description

D-Leucine, Hydrochloride is the hydrochloride salt form of the D-isomer of the essential branched-chain amino acid leucine. This specific enantiomer is a critical chiral building block and intermediate in the synthesis of pharmaceuticals, peptides, and fine chemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for applications requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for metabolic and neurological drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-leucine residue into peptide sequences for research and therapeutic peptides.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, metabolic pathway analysis, and as a component in cell culture media for specialized research.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in organic chemistry to induce stereoselectivity in chemical reactions.
• Food & Nutrition Research: Used in studies investigating amino acid metabolism, dietary supplements, and the biological effects of D-amino acids.
• Agrochemical Development: Potential intermediate in the synthesis of chiral pesticides or herbicides.

Basic Information

Product Name	D-Leucine, Hydrochloride
CAS No.	27493-26-1
Molecular Formula	C6H13NO2 · HCl
Molecular Weight	167.63 g/mol (Free base: 131.17 g/mol)
Synonyms	(2R)-2-Amino-4-methylpentanoic acid hydrochloride; D-2-Amino-4-methylvaleric acid hydrochloride; (R)-Leucine hydrochloride; H-D-Leu-OH · HCl; D-Leucine HCl; D-Leucine monohydrochloride; (R)-2-Amino-4-methylpentanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our D-Leucine, Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high chemical and chiral purity, including assay, optical rotation, and impurity profile analysis. Certificates of Analysis (COA) with detailed HPLC/Chiral HPLC data are provided to guarantee compliance with your specific research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-14.5° to -16.5° (c=1 in H2O)
Chiral Purity (Chiral HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.