Description

trans-4-Cbz-Aminophenol CAS NO 27489-63-0 is a high-purity, protected amino alcohol derivative, specifically the carbobenzyloxy (Cbz) protected form of 4-aminophenol. This compound serves as a critical chiral building block and versatile intermediate in sophisticated organic synthesis, enabling the controlled introduction of functionalized aromatic amine groups. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing active pharmaceutical ingredients (APIs), ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in constructing pharmacophores with aromatic amine functionality.
• Peptide Chemistry & Protecting Group Strategy: The Cbz (carbobenzyloxy) group serves as a temporary protecting group for amines, allowing for selective reactions in multi-step peptide and heterocycle synthesis.
• Ligand and Catalyst Preparation: Used to synthesize chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Polymer Science: Monomer or chain extender for creating specialty polyamides, polyurethanes, and epoxy resins with enhanced properties.
• Chemical Biology & Bioconjugation: Useful for modifying biomolecules or surfaces due to its reactive phenolic and protected amine groups.

Basic Information

Product Name	trans-4-Cbz-Aminophenol
CAS No.	27489-63-0
Molecular Formula	C₁₄H₁₃NO₃
Molecular Weight	243.26 g/mol
Synonyms	4-[(Benzyloxy)carbonyl]aminophenol; N-Cbz-4-aminophenol; 4-(Benzyloxycarbonylamino)phenol; 4-Hydroxy-N-(phenylmethoxy)carbonyl]aniline; Carbamic acid, N-(4-hydroxyphenyl)-, phenylmethyl ester; Benzyl (4-hydroxyphenyl)carbamate; (4-Hydroxyphenyl)carbamic acid benzyl ester; trans-4-(N-Carbobenzyloxy)aminophenol
EINECS	Contact for details

Quality Control

Our trans-4-Cbz-Aminophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.