Description

Benzene, [14C(U)] CAS NO 27271-55-2 is a uniformly carbon-14 labeled isotopologue of benzene, a fundamental aromatic hydrocarbon. This radiolabeled compound is essential for precise metabolic and environmental fate studies, providing critical data for regulatory submissions and advanced research. It is primarily utilized by pharmaceutical R&D teams, agrochemical developers, and environmental scientists conducting tracer experiments, drug metabolism and pharmacokinetics (DMPK) studies, and biodegradation pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities in preclinical development.
• Environmental Fate and Biodegradation Research: Tracks the transformation and mineralization pathways of benzene and related compounds in soil, water, and microbial systems.
• Synthesis of Labeled Intermediates: Serves as a key building block for the synthesis of more complex carbon-14 labeled compounds for use in various research programs.
• Mechanistic Biochemical Research: Enables detailed investigation of enzymatic reaction mechanisms and metabolic pathways involving aromatic ring systems.
• Analytical Method Development: Acts as a standard or tracer in developing and validating sensitive analytical methods like LC-MS/MS for benzene detection.

Basic Information

Product Name	Benzene, [14C(U)]
CAS No.	27271-55-2
Molecular Formula	C146H6
Molecular Weight	84.09 (for [14C(U)]; theoretical average)
Synonyms	Benzene-14C(U); Uniformly Labeled Carbon-14 Benzene; [U-14C]Benzene; Radiolabeled Benzene; 14C-Benzene; Benzene (carbon-14); Cyclohexa-1,3,5-triene-14C(U)
EINECS	Contact for details

Quality Control

Every batch of Benzene, [14C(U)] is produced and analyzed under strict quality control protocols to ensure exceptional chemical and radiochemical purity, specific activity, and stability. Our quality commitment includes verification of identity, assay, and radiochemical purity by techniques such as HPLC with radiometric detection and GC-MS. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for all critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a dedicated, well-ventilated area at controlled room temperature (15-25°C) or as specified on the label. For long-term stability, storage under inert atmosphere (e.g., argon or nitrogen) in amber vials is recommended. Users must adhere to all local and international regulations for the safe storage of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR/NMR)	Conforms to structure
Assay (Radiochemical Purity, HPLC)	≥ 98%
Chemical Purity (GC)	≥ 99%
Specific Activity	Batch-specific (mCi/mmol)
Solvent	Toluene or other specified inert solvent
Concentration	Batch-specific (mCi/mL or µCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.