Description

(2S,3S)-3-Hydroxy-2-(4-Methoxy-Phenyl)-2,3-Dihydro-5H-Benzo[B][1,4]Thiazepin-4-One CAS NO 27068-88-8 is a high-purity chiral benzothiazepine derivative, a crucial advanced pharmaceutical intermediate. Its defined stereochemistry and complex heterocyclic structure make it a valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel benzothiazepine-based drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical precursor in multi-step synthetic routes for potential CNS and cardiovascular drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Asymmetric Synthesis: Employed as a stereochemically defined template for exploring new catalytic asymmetric transformations.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Investigated for its potential interaction with biological targets such as ion channels or receptors.

Basic Information

Product Name	(2S,3S)-3-Hydroxy-2-(4-Methoxy-Phenyl)-2,3-Dihydro-5H-Benzo[B][1,4]Thiazepin-4-One
CAS No.	27068-88-8
Molecular Formula	C₁₇H₁₅NO₃S
Molecular Weight	313.37 g/mol
Synonyms	(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one; (2S,3S)-2-(4-Methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one; 27068-88-8; (2S-cis)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,4-benzothiazepin-4-one; Benzo[b][1,4]thiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)-; (2S,3S)-2-(p-Methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
EINECS	Contact for details

Quality Control

Our (2S,3S)-3-Hydroxy-2-(4-Methoxy-Phenyl)-2,3-Dihydro-5H-Benzo[B][1,4]Thiazepin-4-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and mass spectrometry for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.