Description

Methyl 1,4-Dioxaspiro[4.5]Decane-8-Carboxylate is a versatile spirocyclic ester compound that serves as a valuable protected intermediate in advanced organic synthesis. Its core value lies in the 1,3-dioxolane ring, which acts as a robust protecting group for ketones, enabling complex multi-step reactions in sensitive molecule construction. This high-purity building block is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fragrance industries who require reliable, well-defined intermediates for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of complex drug candidates, particularly those containing cyclohexanone or related carbonyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the spirocyclic structure imparts specific biological activity or stability.
• Fragrance and Flavor Chemistry: Serves as a precursor for musk-like odorants and other specialty aroma chemicals due to its complex, hindered molecular framework.
• Academic and R&D Laboratories: Employed as a model compound or building block in methodological studies for new synthetic transformations involving protected carbonyls.
• Fine Chemical Production: Integral to the custom synthesis of specialty chemicals, dyes, and functional materials requiring high-purity, advanced intermediates.
• Process Chemistry Development: Used for scaling up synthetic routes where a stable, easily handled ketone protecting group is required under various reaction conditions.

Basic Information

Product Name	Methyl 1,4-Dioxaspiro[4.5]Decane-8-Carboxylate
CAS No.	26845-47-6
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	8-Methoxycarbonyl-1,4-dioxaspiro[4.5]decane; Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate; 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, methyl ester; Spiro[1,3-dioxolane-2,1'-cyclohexane]-8-carboxylic acid, methyl ester; Cyclohexanone ethylene ketal-8-carboxylic acid methyl ester; Methyl cyclohexanone ethylene ketal-8-carboxylate; 8-Carbomethoxy-1,4-dioxaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our Methyl 1,4-Dioxaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider using an inert atmosphere to maintain optimal purity. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.