Description

4-Hydroxybenzotriazole (CAS NO 26725-51-9) is a versatile heterocyclic compound that serves as a critical reagent in modern synthetic chemistry. Its primary value lies in its role as a highly effective peptide coupling additive, significantly reducing racemization and improving yields in amide bond formation. This makes it an indispensable material for pharmaceutical R&D, peptide synthesis, and the production of fine chemicals and agrochemical intermediates.

Application

• As a key additive in peptide coupling reagents (e.g., with HOBt, HATU) to suppress racemization during solid-phase and solution-phase peptide synthesis.
• As a catalyst and coupling agent in the synthesis of amides, esters, and other pharmaceutical intermediates.
• As a building block in organic synthesis for the preparation of more complex benzotriazole derivatives.
• In research and development of active pharmaceutical ingredients (APIs) and bioactive compounds.
• In the synthesis of polymers and specialty materials requiring controlled amide linkages.
• As a corrosion inhibitor in certain industrial formulations (subject to specific grade suitability).

Basic Information

Product Name	4-Hydroxybenzotriazole
CAS No.	26725-51-9
Molecular Formula	C6H5N3O
Molecular Weight	135.12 g/mol
Synonyms	HOBt; 1H-Benzotriazol-1-ol; Hydroxybenzotriazole; 1-Hydroxy-1H-benzotriazole; 1-Hydroxybenzotriazole; Benzotriazol-1-ol; NSC 155060; 1-Hydroxy-7-azabenzotriazole
EINECS	247-941-3

Quality Control

Our 4-Hydroxybenzotriazole is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); ensure containers are kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	156°C - 160°C
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.