Description

Glycine, n-[n-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-Oxocholan-24-Yl]Glycyl]- (9Ci) is a specialized cholic acid derivative, a glycine-conjugated bile acid analog of significant interest in advanced biochemical research and pharmaceutical development. This high-purity compound serves as a critical intermediate and reference standard for the synthesis and study of novel therapeutic agents targeting metabolic and hepatic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for liver disease, cholesterol metabolism, and gastrointestinal disorder research.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel bile acid-based therapeutics and prodrugs.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies related to bile acid metabolism and transport.
• Metabolic Pathway Analysis: Employed in in vitro and in vivo studies to investigate cholesterol homeostasis and liver function.
• Diagnostic Reagent Development: Serves as a calibrant or component in the development of diagnostic assays for liver and metabolic disorders.
• Academic Research: Utilized in university and institutional labs for fundamental research on receptor ligands (e.g., FXR, TGR5) and signaling pathways.

Basic Information

Item	Details
Product Name	Glycine, n-[n-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-Oxocholan-24-Yl]Glycyl]- (9Ci)
CAS No.	26563-58-6
Molecular Formula	C₂₆H₄₃NO₇
Molecular Weight	481.63 g/mol
Synonyms	N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycylglycine; Glycocholic acid glycine conjugate; Taurochenodeoxycholic acid glycine derivative; Cholylglycylglycine; Bile acid-glycine dipeptide; 3α,7α,12α-Trihydroxy-5β-cholan-24-oyl-glycyl-glycine; N-(3α,7α,12α-Trihydroxy-5β-cholan-24-oyl)-glycyl-glycine
EINECS	Contact for details

Quality Control

Our Glycine, n-[n-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-Oxocholan-24-Yl]Glycyl]- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.