Description

(R)-Phenyl[[(2,2,2-Trichloroethoxy)Carbonyl]Amino]Acetic Acid CAS NO 26553-34-4 is a high-purity chiral building block and protected amino acid derivative, essential for advanced organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric purity in final products. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in peptide synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of enantiomerically pure drugs, particularly in peptide-based therapeutics.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to control stereochemistry.
• Asymmetric Synthesis: Serves as a building block for constructing complex molecular architectures with defined stereocenters in medicinal chemistry.
• Chemical Research & Development: Employed in academic and industrial labs for developing new synthetic methodologies and novel bioactive compounds.
• Protecting Group Chemistry: The 2,2,2-trichloroethoxycarbonyl (Troc) group provides a base-labile protecting strategy for amines in multi-step syntheses.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in chiral analysis.

Basic Information

Product Name	(R)-Phenyl[[(2,2,2-Trichloroethoxy)Carbonyl]Amino]Acetic Acid
CAS No.	26553-34-4
Molecular Formula	C11H10Cl3NO4
Molecular Weight	326.56 g/mol
Synonyms	(R)-N-[(2,2,2-Trichloroethoxy)carbonyl]phenylglycine; (R)-2-[[(2,2,2-Trichloroethoxy)carbonyl]amino]-2-phenylacetic acid; (R)-Troc-Phenylglycine; (R)-N-Troc-Phenylglycine; (R)-α-[[(2,2,2-Trichloroethoxy)carbonyl]amino]benzenacetic acid; (R)-2-Phenyl-2-[(2,2,2-trichloroethoxycarbonyl)amino]acetic acid; D-N-Troc-Phenylglycine; (R)-N-(Troc)phenylglycine
EINECS	Contact for details

Quality Control

Our (R)-Phenyl[[(2,2,2-Trichloroethoxy)Carbonyl]Amino]Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.