Description

3-Iodooxetane is a high-value, four-membered heterocyclic building block containing both an oxetane ring and an iodine substituent. This unique bifunctional structure makes it a versatile intermediate for synthesizing complex molecules in pharmaceutical and advanced material research. It is particularly sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel molecular scaffolds and introducing functional handles for further derivatization.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting novel ring systems.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Polymer and Material Science: Employed to introduce polar, rigid oxetane units into polymers, affecting thermal and mechanical properties.
• Cross-Coupling Reactions: The iodine atom acts as an excellent leaving group in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research applications due to its reactive handles.

Basic Information

Item	Details
Product Name	3-Iodooxetane
CAS No.	26272-85-5
Molecular Formula	C3H5IO
Molecular Weight	183.98 g/mol
Synonyms	3-Iodooxetane; Oxetane, 3-iodo-; 3-Iodo-1-oxacyclobutane; 3-Iodocyclopropyl methyl ether; 26272-85-5; 3-iodooxacyclobutane; 3-iodo-oxetane
EINECS	Contact for details

Quality Control

Our 3-Iodooxetane is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including NMR, GC/HPLC, and residual solvent analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature, handling and packaging should minimize exposure to light. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.