Description

1-Hydroxy-6-(Trifluoromethyl)Benzotriazole is a specialized heterocyclic compound that serves as a key intermediate and reagent in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl and hydroxyl groups on the benzotriazole scaffold, enabling precise chemical transformations. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity building blocks for creating novel molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the incorporation of a trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the benzotriazole moiety can contribute to specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of novel polymers, dyes, and electronic materials that benefit from its unique structural and electronic properties.
• Peptide Coupling Reagent: Functions as an activating agent or additive in peptide synthesis protocols to improve yield and reduce racemization.
• Chemical Biology Probe Development: Utilized as a scaffold for creating molecular probes and inhibitors to study enzyme function and biological pathways.

Basic Information

Product Name	1-Hydroxy-6-(Trifluoromethyl)Benzotriazole
CAS No.	26198-21-0
Molecular Formula	C7H4F3N3O
Molecular Weight	203.12 g/mol
Synonyms	6-(Trifluoromethyl)-1H-benzotriazol-1-ol; 1-Hydroxy-6-trifluoromethylbenzotriazole; 1H-Benzotriazol-1-ol, 6-(trifluoromethyl)-; HOAt-CF3; 1-Hydroxy-6-(trifluoromethyl)-1H-benzotriazole; 6-Trifluoromethyl-1-hydroxybenzotriazole; 1-Hydroxy-7-azabenzotriazole-4-trifluoromethyl (tautomer)
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-6-(Trifluoromethyl)Benzotriazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.