Description

1-Hydroxy-6-Nitrobenzotriazole is a specialized heterocyclic compound that serves as a key reagent and intermediate in advanced organic synthesis. Its unique structure, combining a benzotriazole core with hydroxyl and nitro substituents, makes it valuable for facilitating challenging coupling reactions and as a building block for complex molecules. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance intermediates for process development and scale-up.

Application

• Peptide Coupling Reagent: Acts as an effective additive or catalyst in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) to suppress racemization and improve coupling efficiency.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and other biologically active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Specialty Chemical Manufacturing: Employed as a precursor for dyes, pigments, and performance chemicals.
• Research & Development: A valuable tool for academic and industrial R&D chemists exploring new synthetic methodologies and heterocyclic chemistry.
• Polymer Chemistry: Can be utilized in the synthesis of functional polymers and materials science applications.

Basic Information

Product Name	1-Hydroxy-6-Nitrobenzotriazole
CAS No.	26185-63-7
Molecular Formula	C₆H₄N₄O₃
Molecular Weight	180.12 g/mol
Synonyms	6-Nitro-1H-benzotriazol-1-ol; 1-Hydroxy-6-nitro-1H-benzotriazole; HONB; 6-Nitro-1-hydroxybenzotriazole; 1H-Benzotriazol-1-ol, 6-nitro-; 6-Nitrobenzotriazol-1-ol; 1-Hydroxy-6-nitrobenzotriazole
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-6-Nitrobenzotriazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.