Description

(S)-(+)-α-Methoxyphenylacetic Acid is a high-purity chiral carboxylic acid, serving as a critical building block in asymmetric synthesis. Its primary value lies in its role as a versatile resolving agent and chiral auxiliary for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and advanced material sectors who require precise stereochemical control.

Application

• Chiral Resolution Agent: Widely used for the separation of racemic mixtures of amines, amino acids, and other basic pharmaceuticals.
• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for cardiovascular and central nervous system drugs.
• Asymmetric Synthesis: Employed as a chiral auxiliary in stereoselective reactions, including alkylations, aldol reactions, and Diels-Alder cycloadditions.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in homogeneous catalysis.
• Analytical Standard: Utilized as a reference standard in chiral HPLC and other analytical methods for method development and quality control.

Basic Information

Product Name	(S)-(+)-α-Methoxyphenylacetic Acid
CAS No.	26164-26-1
Molecular Formula	C10H12O3
Molecular Weight	180.20 g/mol
Synonyms	(S)-(+)-2-Methoxy-2-phenylacetic acid; (S)-O-Methylmandelic acid; (S)-α-Methoxyphenylacetic acid; L-α-Methoxyphenylacetic acid; (S)-MPA; (2S)-2-Methoxy-2-phenylacetic acid; (S)-(+)-2-Methoxy-2-phenylethanoic acid; (S)-Methoxy(phenyl)acetic acid
EINECS	Contact for details

Quality Control

Our (S)-(+)-α-Methoxyphenylacetic Acid is manufactured under strict quality management systems. We guarantee high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	75 - 78 °C
Specific Rotation [α]20/D	+150° to +160° (c=1 in methanol)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.