Description

(+)-Chloromethyl Isomenthyl Ether CAS NO 26127-08-2 is a chiral ether derivative of isomenthol, valued for its role as a versatile chiral building block and protecting group in sophisticated organic synthesis. Its importance lies in enabling the stereoselective construction of complex molecules, particularly in the pharmaceutical and fine chemical sectors. This high-purity intermediate is essential for research chemists and production facilities developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty fragrances where precise stereochemistry is critical.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Used in the stereoselective production of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs and antiviral agents.
• Agrochemical Precursor: Serves as a key building block for synthesizing enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Employed in the creation of high-value aroma chemicals and flavor compounds where the specific isomenthyl scaffold imparts desired olfactory properties.
• Academic and Industrial Research: A valuable reagent for methodological development in asymmetric synthesis and catalysis studies.
• Protecting Group Chemistry: Utilized for the temporary protection of hydroxyl groups during multi-step synthetic sequences, particularly where base-sensitive substrates are involved.

Basic Information

Product Name	(+)-Chloromethyl Isomenthyl Ether
CAS No.	26127-08-2
Molecular Formula	C11H21ClO
Molecular Weight	204.74 g/mol
Synonyms	(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl chloromethyl ether; (+)-Chloromethyl isomenthyl ether; Isomenthyl chloromethyl ether; (1R,2S,5R)-(-)-Isomenthol chloromethyl ether; Chloromethyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether; (1R,2S,5R)-2-(1-Methylethyl)-5-methylcyclohexyl chloromethyl ether
EINECS	Contact for details

Quality Control

Our (+)-Chloromethyl Isomenthyl Ether is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by GC or HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Chiral Purity (Chiral GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation [α]	Contact for details
Refractive Index	Contact for details
Density	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.