Description

n-Acetyl-2,3-Dehydro-2-Deoxyneuraminic Acid, Methyl Ester is a key synthetic intermediate and derivative of neuraminic acid, a fundamental sialic acid building block. This compound is essential for research and development in glycobiology and medicinal chemistry, serving as a crucial precursor for synthesizing more complex sialic acid analogs and inhibitors. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions focused on carbohydrate-based drug discovery, antiviral studies, and enzyme mechanism investigations.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel sialidase (neuraminidase) inhibitors with potential antiviral and antibacterial applications.
• Glycobiology Research: Used as a substrate or inhibitor in enzymatic studies to understand the role of sialidases in cellular recognition and signaling pathways.
• Diagnostic Reagent Development: Serves as a precursor for labeling compounds used in assays to detect sialic acid-related enzymes or metabolic disorders.
• Chemical Biology Probes: Acts as a starting material for creating activity-based probes to profile neuraminidase activity in complex biological samples.
• Academic & Industrial R&D: Fundamental research tool for studying carbohydrate-protein interactions, glycan biosynthesis, and the development of glycomimetic drugs.

Basic Information

Product Name	n-Acetyl-2,3-Dehydro-2-Deoxyneuraminic Acid, Methyl Ester
CAS No.	25875-99-4
Molecular Formula	C12H17NO8
Molecular Weight	303.27 g/mol
Synonyms	2-Deoxy-2,3-didehydro-N-acetylneuraminic Acid Methyl Ester; DANA Methyl Ester; Neu5Ac2en Methyl Ester; Methyl 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonate; 2,3-Didehydro-2-deoxy-N-acetylneuraminic Acid Methyl Ester; Methyl (5S)-5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonate; Zanamivir Intermediate
EINECS	Contact for details

Quality Control

Our n-Acetyl-2,3-Dehydro-2-Deoxyneuraminic Acid, Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.