Description

Nh-(Peg2-Oh)2 CAS NO 25743-12-8 is a specialized bifunctional polyethylene glycol (PEG) derivative, featuring dual hydroxyl-terminated arms. This compound is valued for its role as a versatile hydrophilic linker and spacer in advanced material synthesis and bioconjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer industries for applications requiring controlled solubility and molecular architecture.

Application

• Pharmaceutical Linker: Used in the synthesis of prodrugs and antibody-drug conjugates (ADCs) to improve solubility and pharmacokinetics.
• Bioconjugation Spacer: Serves as a hydrophilic tether for attaching peptides, proteins, or fluorescent dyes, reducing steric hindrance.
• Polymer Chemistry: Acts as a building block or initiator for creating functionalized, water-soluble polymers and hydrogels.
• Surface Modification: Employed to PEGylate nanoparticles, quantum dots, or other surfaces to enhance biocompatibility and stability.
• Cross-linking Agent: Utilized in the preparation of cross-linked networks for controlled release or tissue engineering scaffolds.
• Chemical Intermediate: A key precursor for further functionalization to create more complex PEG-based derivatives.

Basic Information

Product Name	Nh-(Peg2-Oh)2 CAS NO 25743-12-8
CAS No.	25743-12-8
Molecular Formula	C8H18N2O5
Molecular Weight	222.24 g/mol
Synonyms	1,1'-[(Nitrilodimethylene)bis(oxy-2,1-ethanediyl)]bis-2-propanol; 2,2'-(2,2'-Oxybis(ethane-2,1-diyl)bis(oxy))bis(N-(2-hydroxypropyl)acetamide); N,N-Bis[2-[2-(2-hydroxypropoxy)ethoxy]ethyl]amine; PEGylated diol amine; Bifunctional PEG diol; Amino-PEG-diol; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Nh-(Peg2-Oh)2 is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.