Description

4-Phenylethynyl-Benzoic Acid is a high-purity, functionalized aromatic carboxylic acid characterized by its terminal alkyne moiety. This compound is a versatile and valuable organic building block for advanced material synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-cancer drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, leveraging its aromatic and alkyne functionality.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and advanced organic frameworks (MOFs/COFs).
• Click Chemistry: The terminal alkyne group makes it an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and polymer functionalization.
• Organic Electronic Materials: Employed in the research of organic semiconductors and conductive polymers due to its conjugated phenylethynyl-benzoic acid structure.
• Chemical Research: A fundamental reagent in academic and industrial laboratories for studying Sonogashira coupling and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	4-Phenylethynyl-Benzoic Acid
CAS No.	25739-23-5
Molecular Formula	C15H10O2
Molecular Weight	222.24 g/mol
Synonyms	4-(Phenylethynyl)benzoic Acid; Benzoic acid, 4-(2-phenylethynyl)-; p-(Phenylethynyl)benzoic Acid; 4-Ethynylbenzoic Acid Phenyl Derivative; [1,1'-Biphenyl]-4-carboxylic acid, 4'-ethynyl-; 4-Carboxyphenylphenylacetylene
EINECS	Contact for details

Quality Control

Our 4-Phenylethynyl-Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	205 - 210 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.