Description

5-Aza-Spiro[2.5]Octane is a high-value, nitrogen-containing spirocyclic building block with the CAS number 25337-01-3. This compound is prized for its unique three-dimensional structure, which is critical for modulating the physicochemical properties and biological activity of advanced molecules. It is an essential intermediate for medicinal chemistry research and development, particularly in the synthesis of novel pharmaceuticals targeting central nervous system disorders and other therapeutic areas. Its rigid scaffold is instrumental in creating compounds with improved selectivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological targets.
• Medicinal Chemistry: Used as a privileged scaffold in fragment-based drug design and lead optimization to explore novel chemical space.
• Agrochemical Research: Employed in the synthesis of novel compounds with potential herbicidal or insecticidal activity.
• Chemical Biology: Serves as a probe or tool compound for studying enzyme mechanisms and protein-ligand interactions.
• Academic & Contract Research: Utilized in universities and CROs for fundamental organic synthesis and method development projects.

Basic Information

Product Name	5-Aza-Spiro[2.5]Octane
CAS No.	25337-01-3
Molecular Formula	C7H13N
Molecular Weight	111.18 g/mol
Synonyms	5-Azaspiro[2.5]octane; 1-Azaspiro[2.5]octane; 5-Aza-spiro[2.5]octane; Azaspirooctane; Spiro[cyclopropane-1,2'-pyrrolidine]; 2,5-Diazaspiro[2.5]octane (related); 1-Aza-spiro[2.5]octane
EINECS	Contact for details

Quality Control

Our 5-Aza-Spiro[2.5]Octane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.