Description

2-Hydroxy-4-(Trifluoromethyl)Quinoline is a versatile fluorinated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl substituent, makes it a valuable precursor for developing compounds with enhanced biological activity and material properties. This high-purity intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders, anti-infectives, and anti-cancer agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science: Serves as a monomer or functional additive in the creation of advanced polymers, liquid crystals, and organic light-emitting diodes (OLEDs) due to its electron-withdrawing characteristics.
• Coordination Chemistry & Catalysis: Acts as a chelating ligand for metal complexes used in homogeneous catalysis and as functional materials.
• Fluorine Chemistry Research: A fundamental compound for studying structure-activity relationships (SAR) in medicinal chemistry and the effects of fluorination on molecular properties.

Basic Information

Item	Details
Product Name	2-Hydroxy-4-(Trifluoromethyl)Quinoline
CAS No.	25199-84-2
Molecular Formula	C₁₀H₆F₃NO
Molecular Weight	213.16 g/mol
Synonyms	4-(Trifluoromethyl)-2-quinolinol; 4-(Trifluoromethyl)quinolin-2-ol; 2-Quinolinol, 4-(trifluoromethyl)-; 2-Hydroxy-4-trifluoromethylquinoline; 4-Trifluoromethyl-2-hydroxyquinoline; 2-Hydroxy-4-(trifluoromethyl)quinoline; 4-(Trifluoromethyl)-2-hydroxyquinoline
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethyl)Quinoline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.