Description

3-(2,2-Dimethoxyethyl)-3-Methyl-3H-Diazirine is a specialized, highly reactive diazirine-based photoaffinity labeling reagent. This compound matters for its ability to form covalent bonds upon photolysis with ultraviolet light, enabling the study of biomolecular interactions and binding sites. It is primarily needed by researchers and manufacturers in the fields of chemical biology, proteomics, and pharmaceutical development for creating irreversible probes and cross-linking agents.

Application

• Photoaffinity Labeling (PAL): A critical tool for mapping protein-ligand interactions, binding pockets, and active sites in drug discovery and biochemical research.
• Proteomics & Chemical Biology: Used to synthesize probes for target identification, understanding metabolic pathways, and studying protein-protein interactions.
• Material Science Surface Modification: Employed to functionalize surfaces and polymers through photochemical cross-linking for creating advanced materials.
• Bioconjugation & Probe Synthesis: Serves as a key intermediate for constructing labeled nucleotides, lipids, and other biomolecules for imaging and diagnostic applications.
• Pharmaceutical Intermediate: Utilized in the synthesis of more complex molecules where a stable, photo-activatable moiety is required.

Basic Information

Product Name	3-(2,2-Dimethoxyethyl)-3-Methyl-3H-Diazirine
CAS No.	25055-98-5
Molecular Formula	C7H14N2O2
Molecular Weight	158.20 g/mol
Synonyms	3-Methyl-3-(2,2-dimethoxyethyl)diazirine; 3H-Diazirine, 3-(2,2-dimethoxyethyl)-3-methyl-; 3-(2,2-Dimethoxyethyl)-3-methyldiazirine; Diazirine Photoaffinity Labeling Reagent; DADMB (3-Diazo-2,2-dimethoxy-4-methylbutane precursor); Photo-activatable Crosslinker
EINECS	Contact for details

Quality Control

Our 3-(2,2-Dimethoxyethyl)-3-Methyl-3H-Diazirine is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, essential for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability. We adhere to relevant quality management standards to guarantee reliable supply and product integrity for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures (typically 2-8°C or as specified). Due to its highly volatile and light-sensitive nature, minimize exposure to air, heat, and light during handling. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.