Description

2-(3-Methyl-3H-diazirin-3-yl)ethanamine hydrochloride is a specialized chemical building block and photoaffinity labeling reagent. This compound matters for researchers and manufacturers requiring precise, covalent cross-linking in biochemical and pharmaceutical studies. It is primarily needed by professionals in life sciences R&D, pharmaceutical development, and advanced material synthesis for probing molecular interactions and developing targeted therapies.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently capturing transient or weak biomolecular interactions upon photoactivation, essential for drug target identification and mechanism-of-action studies.
• Proteomics and Chemical Biology: Used to tag proteins, nucleic acids, or other biomolecules for isolation, purification, and characterization workflows.
• Bioconjugation and Linker Chemistry: Serves as a versatile amine-containing linker that can be functionalized with various probes (e.g., fluorophores, biotin, affinity tags) for creating sophisticated molecular tools.
• Pharmaceutical Research: Employed in the development of novel therapeutic agents, particularly for creating covalent inhibitors or for mapping binding sites.
• Material Science: Potential use in surface functionalization and the creation of photo-crosslinkable polymers or advanced coatings.

Basic Information

Product Name	2-(3-Methyl-3H-diazirin-3-yl)ethanamine Hydrochloride
CAS No.	25055-95-2
Molecular Formula	C5H11ClN3
Molecular Weight	148.61 g/mol
Synonyms	3-[2-Aminoethyl]-3-methyldiazirine Hydrochloride; 2-(3-Methyl-3H-diazirin-3-yl)ethylamine Hydrochloride; 3-(2-Aminoethyl)-3-methyldiazirine HCl; TMDZ-EA HCl; Photoactivatable Ethylamine; Diazirine-PEG1-amine HCl; 3-Methyl-3-(2-aminoethyl)diazirine Hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(3-Methyl-3H-diazirin-3-yl)ethanamine hydrochloride is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. Due to its hygroscopic and strictly light-sensitive nature, the container should be allowed to reach ambient temperature before opening to minimize moisture uptake, and handling should be performed under subdued light conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.