Description

Tetrakis(Methyldiphenylphosphine)Palladium(0) is a highly versatile and efficient palladium(0) catalyst widely used in cross-coupling reactions. This compound matters for its exceptional catalytic activity and selectivity, enabling the formation of carbon-carbon and carbon-heteroatom bonds under mild conditions. It is a critical reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, particularly for scaling up complex synthetic routes. Its stability and defined coordination sphere make it a preferred choice for demanding catalytic transformations.

Application

• Suzuki-Miyaura Cross-Coupling: Catalyzes the coupling of aryl/vinyl boronic acids with aryl/vinyl halides for biaryl synthesis.
• Heck Reaction (Mizoroki-Heck): Facilitates the arylation or alkenylation of olefins.
• Sonogashira Coupling: Enables the coupling of terminal alkynes with aryl or vinyl halides.
• Buchwald-Hartwig Amination: Key catalyst for C-N bond formation between amines and aryl halides.
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Materials Science Research: Employed in the synthesis of conjugated polymers, organic light-emitting diodes (OLEDs), and other functional materials.
• Fine Chemical Manufacturing: Applied in the synthesis of specialty chemicals, ligands, and fragrances.

Basic Information

Product Name	Tetrakis(Methyldiphenylphosphine)Palladium(0)
CAS No.	24981-80-4
Molecular Formula	C52H52P4Pd
Molecular Weight	915.27 g/mol
Synonyms	Palladium(0) tetrakis(methyldiphenylphosphine); Tetrakis(methyldiphenylphosphine)palladium; Pd[PPh2Me]4; Palladium-tetrakis(methyl-diphenylphosphine); Tetrakis(methyl-diphenyl-phosphine)palladium(0); Pd(PPh2CH3)4; Palladium(0) tetrakis(methyl-diphenylphosphine)
EINECS	Contact for details

Quality Control

Our Tetrakis(Methyldiphenylphosphine)Palladium(0) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is analyzed to confirm identity, purity, and activity. A comprehensive Certificate of Analysis (COA) detailing specifications such as palladium content, phosphine ligand ratio, and solvent residues is provided. We support compliance with relevant GMP and ISO 9001 standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is light-sensitive and easily oxidized; prolonged exposure to air or moisture should be avoided to maintain catalytic activity. Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Palladium (Pd) Content	≥ 11.6 %
Purity (HPLC)	≥ 98.0 %
Solvent Residues (GC)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.