Description

4-(Difluoromethylsulfonyl)Nitrobenzene is a high-purity, specialized organic intermediate featuring a unique combination of nitro, sulfonyl, and difluoromethyl functional groups. This compound is valued for its role as a critical building block in advanced synthetic chemistry, enabling the introduction of fluorinated motifs into target molecules. It is primarily sought by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where the difluoromethylsulfonyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the electron-withdrawing properties of the nitro and sulfonyl groups.
• Fluorine Chemistry Studies: An important reagent for investigating new fluorination methodologies and the properties of fluorinated aromatic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in proprietary client synthesis projects.

Basic Information

Product Name	4-(Difluoromethylsulfonyl)Nitrobenzene
CAS No.	24906-74-9
Molecular Formula	C7H5F2NO4S
Molecular Weight	237.18 g/mol
Synonyms	1-Nitro-4-(difluoromethylsulfonyl)benzene; p-(Difluoromethylsulfonyl)nitrobenzene; 4-Nitro-α,α-difluorobenzenemethanesulfonic Acid (related form); Benzene, 1-(difluoromethylsulfonyl)-4-nitro-; DFMS-NB; NSC 403120; α,α-Difluoro-4-nitrobenzenemethanesulfonic Acid (related form)
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethylsulfonyl)Nitrobenzene is produced and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.